TRADITIONAL ESCALATION APPROACH:
MS Diagnosis → Platform DMT (IFN/GA/Teriflunomide) 
→ Monitor 6-12 months 
→ Disease Activity? 
   → YES: Switch to Moderate DMT (Fumarate/S1P)
   → Monitor 6-12 months
   → Disease Activity?
      → YES: Switch to High-Efficacy DMT
      → Result: Cumulative disability, brain volume loss

EARLY INTENSIVE APPROACH:
MS Diagnosis → Risk Stratification (Clinical + MRI + Biomarkers)
→ High-Efficacy DMT from start
→ Result: Maximal disease suppression, preserved brain health